Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties

The insulin-like growth factor (IGF) axis has been implicated in the progression of malignant disease and identified as a clinically important therapeutic target. Several IGF-1 receptor (IGF-1R) targeting drugs including humanized monoclonal antibodies have advanced to phase II/III clinical trials,...

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Vydáno v:Sci Rep
Hlavní autoři: Vaniotis, George, Moffett, Serge, Sulea, Traian, Wang, Ni, Elahi, S. Mehdy, Lessard, Etienne, Baardsnes, Jason, Perrino, Stephanie, Durocher, Yves, Frystyk, Jan, Massie, Bernard, Brodt, Pnina
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255772/
https://ncbi.nlm.nih.gov/pubmed/30478273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35407-2
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