IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation

As previously reported, chronic lymphocytic leukemia (CLL) cells show constitutive Notch1/2 activation and express the Notchligand Jagged1. Despite increasing knowledge of the impact of Notch alterations on CLL biology and pathogenesis, the role of Jagged1 expressed in CLL cells remains undefined. I...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: De Falco, Filomena, Del Papa, Beatrice, Baldoni, Stefano, Sabatini, Rita, Falzetti, Franca, Di Ianni, Mauro, Martelli, Maria Paola, Mezzasoma, Federica, Pelullo, Maria, Marconi, Pierfrancesco, Sportoletti, Paolo, Screpanti, Isabella, Rosati, Emanuela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255763/
https://ncbi.nlm.nih.gov/pubmed/30478302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1185-6
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