Bepridil exhibits anti‐leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

Dysregulated NOTCH1 signaling, by either gene mutations or microenvironment interactions, has been increasingly linked to chronic lymphocytic leukemia (CLL). Thus, inhibiting NOTCH1 activity represents a potential therapeutic opportunity for this disease. Using gene expression‐based screening, we id...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Int J Cancer
Main Authors: Baldoni, Stefano, Del Papa, Beatrice, Dorillo, Erica, Aureli, Patrizia, De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Varasano, Emanuela, Cecchini, Debora, Zei, Tiziana, Di Tommaso, Ambra, Rosati, Emanuela, Alexe, Gabriela, Roti, Giovanni, Stegmaier, Kimberly, Di Ianni, Mauro, Falzetti, Franca, Sportoletti, Paolo
פורמט: Artigo
שפה:Inglês
יצא לאור: John Wiley and Sons Inc. 2018
נושאים:
Cancer Therapy and Prevention
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055653/
https://ncbi.nlm.nih.gov/pubmed/29508386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31355
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