IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation

As previously reported, chronic lymphocytic leukemia (CLL) cells show constitutive Notch1/2 activation and express the Notchligand Jagged1. Despite increasing knowledge of the impact of Notch alterations on CLL biology and pathogenesis, the role of Jagged1 expressed in CLL cells remains undefined. I...

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Vydáno v:Cell Death Dis
Hlavní autoři: De Falco, Filomena, Del Papa, Beatrice, Baldoni, Stefano, Sabatini, Rita, Falzetti, Franca, Di Ianni, Mauro, Martelli, Maria Paola, Mezzasoma, Federica, Pelullo, Maria, Marconi, Pierfrancesco, Sportoletti, Paolo, Screpanti, Isabella, Rosati, Emanuela
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255763/
https://ncbi.nlm.nih.gov/pubmed/30478302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1185-6
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