Effective Targeting of TAG72(+) Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells

Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expression of tumor-associated antigens, as well as limi...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Murad, John P., Kozlowska, Anna K., Lee, Hee Jun, Ramamurthy, Maya, Chang, Wen-Chung, Yazaki, Paul, Colcher, David, Shively, John, Cristea, Mihaela, Forman, Stephen J., Priceman, Saul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254427/
https://ncbi.nlm.nih.gov/pubmed/30510550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02268
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