Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding

Nuclear receptor farnesoid X receptor (FXR) functions as the major bile acid sensor coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Because of its central role in metabolism, FXR represents an important drug target to manage metabolic and other di...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Wang, Na, Zou, Qingan, Xu, Jinxin, Zhang, Jiancun, Liu, Jinsong
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254343/
https://ncbi.nlm.nih.gov/pubmed/30275017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004652
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items