1335. Safety and Pharmacokinetic Profile of PC786, a Novel Inhibitor of Respiratory Syncytial Virus L-protein Polymerase, in a Single and Multiple-Ascending Dose Study in Healthy Volunteer and Mild Asthmatics

BACKGROUND: RSV is the most common cause of bronchiolitis in infants and is responsible for severe respiratory infections in the elderly and immunocompromised populations. RSV replicates in the columnar epithelial cells of the proximal and distal airways which are accessible to inhaled therapies. PC...

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Vydáno v:Open Forum Infect Dis
Hlavní autoři: Cass, Lindsey, Davis, Amanda, Murray, Alison, Woodward, Kathy, Ito, Kazuhiro, Strong, Pete, Rapeport, Garth
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6253606/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1167
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