1343. Prophylactic Dosing of Baloxavir Acid Eliminates Mortality in Mice Lethal Influenza A Virus Infection Model

BACKGROUND: Baloxavir acid (BXA), an active form of orally available prodrug baloxavir marboxil (BXM, formerly S-033188), is a novel small molecule inhibitor of cap-dependent endonuclease (CEN) of influenza A and B virus, and was recently launched for the treatment of acute and uncomplicated influen...

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Vydáno v:Open Forum Infect Dis
Hlavní autoři: Shano, Shinya, Fukao, Keita, Noshi, Takeshi, Sato, Kenji, Sakuramoto, Masashi, Baba, Kaoru, Shishido, Takao, Naito, Akira
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6253271/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1174
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