1394. A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid (CSF) and Plasma Concentrations of Cefepime

BACKGROUND: For treatment of central nervous system infections caused by GNB, adequate cefepime concentrations are required in the cerebral spinal fluid (CSF) and brain. However, high plasma cefepime exposures have resulted in neurotoxicity. There is a need to understand the real-time pharmacokineti...

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發表在:Open Forum Infect Dis
Main Authors: Liu, Jiajun, Avedissian, Sean, Pais, Gwendolyn, Joshi, Medha, Rhodes, Nathaniel J, Scheetz, Marc H
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252923/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1225
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