Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational In Vivo Rat Model

We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase (P = 0.018) versus that of the controls (P...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Liu, Jiajun, Pais, Gwendolyn M., Avedissian, Sean N., Gilchrist, Annette, Lee, Andrew, Rhodes, Nathaniel J., Hauser, Alan R., Scheetz, Marc H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179599/
https://ncbi.nlm.nih.gov/pubmed/32071049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02300-19
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