Cisplatin-induced renal inflammation is ameliorated by cilastatin nephroprotection

BACKGROUND: Cisplatin is a potent chemotherapeutic drug whose nephrotoxic effect is a major complication and a dose-limiting factor for antitumoral therapy. There is much evidence that inflammation contributes to the pathogenesis of cisplatin-induced nephrotoxicity. We found that cilastatin, a renal...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: Humanes, Blanca, Camaño, Sonia, Lara, Jose Manuel, Sabbisetti, Venkatta, González-Nicolás, María Ángeles, Bonventre, Joseph V., Tejedor, Alberto, Lázaro, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251639/
https://ncbi.nlm.nih.gov/pubmed/28340076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfx005
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