SKI controls MDS-associated chronic TGF-β signaling, aberrant splicing, and stem cell fitness

The transforming growth factor beta (TGF-β) signaling pathway controls hematopoietic stem cell (HSC) behavior in the marrow niche; however, TGF-β signaling becomes chronic in early-stage myelodysplastic syndrome (MDS). Although TGF-β signaling normally induces negative feedback, in early-stage MDS,...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Muench, David E., Ferchen, Kyle, Velu, Chinavenmeni S., Pradhan, Kith, Chetal, Kashish, Chen, Xiaoting, Weirauch, Matthew T., Colmenares, Clemencia, Verma, Amit, Salomonis, Nathan, Grimes, H. Leighton
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251005/
https://ncbi.nlm.nih.gov/pubmed/30249787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-06-860890
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