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Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells

Cytopathic effects (CPEs) are a hallmark of infections. CPEs are difficult to observe due to phototoxicity from classical light microscopy. We report distinct patterns of virus infections in live cells using digital holo-tomographic microscopy (DHTM). DHTM is label-free and records the phase shift o...

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Veröffentlicht in:mSphere
Hauptverfasser: Yakimovich, Artur, Witte, Robert, Andriasyan, Vardan, Georgi, Fanny, Greber, Urs F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249643/
https://ncbi.nlm.nih.gov/pubmed/30463927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00599-18
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