Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier, heterogeneous drug distribution, and development of resistance. Elucidation of relationshi...

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Pubblicato in:Nat Commun
Autori principali: Randall, Elizabeth C., Emdal, Kristina B., Laramy, Janice K., Kim, Minjee, Roos, Alison, Calligaris, David, Regan, Michael S., Gupta, Shiv K., Mladek, Ann C., Carlson, Brett L., Johnson, Aaron J., Lu, Fa-Ke, Xie, X. Sunney, Joughin, Brian A., Reddy, Raven J., Peng, Sen, Abdelmoula, Walid M., Jackson, Pamela R., Kolluri, Aarti, Kellersberger, Katherine A., Agar, Jeffrey N., Lauffenburger, Douglas A., Swanson, Kristin R., Tran, Nhan L., Elmquist, William F., White, Forest M., Sarkaria, Jann N., Agar, Nathalie Y. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249307/
https://ncbi.nlm.nih.gov/pubmed/30464169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07334-3
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