Biological activity of Pt(IV) prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis

We have recently demonstrated that riboflavin (Rf) functions as unconventional bioorthogonal photocatalyst for the activation of Pt(IV) prodrugs. In this study, we show how the combination of light and Rf with two Pt(IV) prodrugs is a feasible strategy for light-mediated pancreatic cancer cell death...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Alonso-de Castro, Silvia, Terenzi, Alessio, Hager, Sonja, Englinger, Bernhard, Faraone, Adriana, Martínez, Javier Calvo, Galanski, Mathea Sophia, Keppler, Bernhard K., Berger, Walter, Salassa, Luca
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249213/
https://ncbi.nlm.nih.gov/pubmed/30464209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35655-2
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