Biological activity of Pt(IV) prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis

We have recently demonstrated that riboflavin (Rf) functions as unconventional bioorthogonal photocatalyst for the activation of Pt(IV) prodrugs. In this study, we show how the combination of light and Rf with two Pt(IV) prodrugs is a feasible strategy for light-mediated pancreatic cancer cell death...

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Publicado en:Sci Rep
Autores principales: Alonso-de Castro, Silvia, Terenzi, Alessio, Hager, Sonja, Englinger, Bernhard, Faraone, Adriana, Martínez, Javier Calvo, Galanski, Mathea Sophia, Keppler, Bernhard K., Berger, Walter, Salassa, Luca
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249213/
https://ncbi.nlm.nih.gov/pubmed/30464209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35655-2
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