Hippo kinases Mst1 and Mst2 sense and amplify IL-2R–STAT5 signaling in regulatory T cells to establish stable regulatory activity

Interleukin-2 (IL-2) and downstream transcription factor STAT5 are important for maintaining regulatory T (Treg) cell homeostasis and function. Treg cells can respond to low IL-2 levels, but the mechanisms of STAT5 activation during partial IL-2 deficiency remain uncertain. We identified the serine-...

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Pubblicato in:Immunity
Autori principali: Shi, Hao, Liu, Chaohong, Tan, Haiyan, Li, Yuxin, Nguyen, Thanh-Long M., Dhungana, Yogesh, Guy, Cliff, Vogel, Peter, Neale, Geoffrey, Rankin, Sherri, Feng, Yongqiang, Peng, Junmin, Tao, Wufan, Chi, Hongbo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249059/
https://ncbi.nlm.nih.gov/pubmed/30413360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.10.010
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