CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Cytochrome P450 2A6 (CYP2A6) catalyzes the metabolism of nicotine and the tobacco-specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Genetic variation in CYP2A6 may affect smoking behavior and contribute to lung cancer risk. A nested case-control study of 197 lung cancer...

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Gepubliceerd in:Carcinogenesis
Hoofdauteurs: Yuan, Jian-Min, Nelson, Heather H., Carmella, Steven G., Wang, Renwei, Kuriger-Laber, Jacquelyn, Jin, Aizhen, Adams-Haduch, Jennifer, Hecht, Stephen S., Koh, Woon-Puay, Murphy, Sharon E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Original Manuscript
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248819/
https://ncbi.nlm.nih.gov/pubmed/28182203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx012
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