CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Cytochrome P450 2A6 (CYP2A6) catalyzes the metabolism of nicotine and the tobacco-specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Genetic variation in CYP2A6 may affect smoking behavior and contribute to lung cancer risk. A nested case-control study of 197 lung cancer...

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Détails bibliographiques
Publié dans:Carcinogenesis
Auteurs principaux: Yuan, Jian-Min, Nelson, Heather H., Carmella, Steven G., Wang, Renwei, Kuriger-Laber, Jacquelyn, Jin, Aizhen, Adams-Haduch, Jennifer, Hecht, Stephen S., Koh, Woon-Puay, Murphy, Sharon E.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Original Manuscript
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248819/
https://ncbi.nlm.nih.gov/pubmed/28182203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgx012
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