Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation

Bridging integrator-1 (BIN1) gene is associated with an increased risk to develop Alzheimer’s disease, a tauopathy characterized by intra-neuronal accumulation of phosphorylated Tau protein as paired helical filaments. Direct interaction of BIN1 and Tau proteins was demonstrated to be mediated throu...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Lasorsa, Alessia, Malki, Idir, Cantrelle, François-Xavier, Merzougui, Hamida, Boll, Emmanuelle, Lambert, Jean-Charles, Landrieu, Isabelle
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6246682/
https://ncbi.nlm.nih.gov/pubmed/30487734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00421
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