Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin

Huntington’s disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using an ultra-sensitive branched fluorescence in situ hybridization...

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Publicat a:Cell Rep
Autors principals: Didiot, Marie-Cécile, Ferguson, Chantal M., Ly, Socheata, Coles, Andrew H., Smith, Abigail O., Bicknell, Alicia A., Hall, Lauren M., Sapp, Ellen, Echeverria, Dimas, Pai, Athma A., DiFiglia, Marian, Moore, Melissa J., Hayward, Lawrence J., Aronin, Neil, Khvorova, Anastasia
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245656/
https://ncbi.nlm.nih.gov/pubmed/30184490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.106
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