Synthesis, pharmacology and preclinical evaluation of (11)C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein

a-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are implicated in the pathology of neurological diseases such as epilepsy and schizophrenia. As pan antagonists for this target are often accompanied with undesired effects at high doses, one of the recent drug discovery approach...

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Bibliografske podrobnosti
izdano v:Eur J Med Chem
Main Authors: Chen, Zhen, Mori, Wakana, Zhang, Xiaofei, Yamasaki, Tomoteru, Dunn, Patrick J., Zhang, Genwei, Fu, Hualong, Shao, Tuo, Zhang, Yiding, Hatori, Akiko, Ma, Longle, Fujinaga, Masayuki, Xie, Lin, Deng, Xiaoyun, Li, Hua, Yu, Qingzhen, Rong, Jian, Josephson, Lee, Ma, Jun-An, Shao, Yihan, Tomita, Susumu, Zhang, Ming-Rong, Liang, Steven H.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245653/
https://ncbi.nlm.nih.gov/pubmed/30145376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.08.019
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