Synthesis, pharmacology and preclinical evaluation of (11)C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein

a-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are implicated in the pathology of neurological diseases such as epilepsy and schizophrenia. As pan antagonists for this target are often accompanied with undesired effects at high doses, one of the recent drug discovery approach...

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Dettagli Bibliografici
Pubblicato in:Eur J Med Chem
Autori principali: Chen, Zhen, Mori, Wakana, Zhang, Xiaofei, Yamasaki, Tomoteru, Dunn, Patrick J., Zhang, Genwei, Fu, Hualong, Shao, Tuo, Zhang, Yiding, Hatori, Akiko, Ma, Longle, Fujinaga, Masayuki, Xie, Lin, Deng, Xiaoyun, Li, Hua, Yu, Qingzhen, Rong, Jian, Josephson, Lee, Ma, Jun-An, Shao, Yihan, Tomita, Susumu, Zhang, Ming-Rong, Liang, Steven H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245653/
https://ncbi.nlm.nih.gov/pubmed/30145376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.08.019
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