Synthesis, pharmacology and preclinical evaluation of (11)C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein

a-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are implicated in the pathology of neurological diseases such as epilepsy and schizophrenia. As pan antagonists for this target are often accompanied with undesired effects at high doses, one of the recent drug discovery approach...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Eur J Med Chem
Hlavní autoři: Chen, Zhen, Mori, Wakana, Zhang, Xiaofei, Yamasaki, Tomoteru, Dunn, Patrick J., Zhang, Genwei, Fu, Hualong, Shao, Tuo, Zhang, Yiding, Hatori, Akiko, Ma, Longle, Fujinaga, Masayuki, Xie, Lin, Deng, Xiaoyun, Li, Hua, Yu, Qingzhen, Rong, Jian, Josephson, Lee, Ma, Jun-An, Shao, Yihan, Tomita, Susumu, Zhang, Ming-Rong, Liang, Steven H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245653/
https://ncbi.nlm.nih.gov/pubmed/30145376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.08.019
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky