Synthesis, pharmacology and preclinical evaluation of (11)C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein

a-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are implicated in the pathology of neurological diseases such as epilepsy and schizophrenia. As pan antagonists for this target are often accompanied with undesired effects at high doses, one of the recent drug discovery approach...

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Dades bibliogràfiques
Publicat a:Eur J Med Chem
Autors principals: Chen, Zhen, Mori, Wakana, Zhang, Xiaofei, Yamasaki, Tomoteru, Dunn, Patrick J., Zhang, Genwei, Fu, Hualong, Shao, Tuo, Zhang, Yiding, Hatori, Akiko, Ma, Longle, Fujinaga, Masayuki, Xie, Lin, Deng, Xiaoyun, Li, Hua, Yu, Qingzhen, Rong, Jian, Josephson, Lee, Ma, Jun-An, Shao, Yihan, Tomita, Susumu, Zhang, Ming-Rong, Liang, Steven H.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245653/
https://ncbi.nlm.nih.gov/pubmed/30145376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.08.019
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