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Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult cancers to treat. It is refractory to most existing therapies, including immunotherapies, due to the presence of an excessive desmoplastic stroma, which restricts penetration of drugs and cytotoxic CD8(+) T cells. Stromal modu...
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| Publicado en: | ACS Nano |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6245606/ https://ncbi.nlm.nih.gov/pubmed/30231203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b02481 |
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