Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway

Mechanical and metabolic cues independently contribute to the regulation of cell and tissue homeostasis. However, how they cross-regulate each other during this process remains largely unknown. Here, we show that cellular metabolism can regulate integrin rigidity-sensing via the sphingolipid metabol...

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Udgivet i:Nat Commun
Main Authors: Boulter, Etienne, Estrach, Soline, Tissot, Floriane S., Hennrich, Marco L., Tosello, Lionel, Cailleteau, Laurence, de la Ballina, Laura R., Pisano, Sabrina, Gavin, Anne-Claude, Féral, Chloé C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242995/
https://ncbi.nlm.nih.gov/pubmed/30451822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07268-w
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