CD98hc (SLC3A2) Loss Protects Against Ras-Driven Tumorigenesis by Modulating Integrin-Mediated Mechanotransduction

CD98hc (SLC3A2) is the heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells. Overexpression of CD98hc occurs widely in cancer cells, and is associated with poor prognosis clinically, but its exact contri...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Estrach, Soline, Lee, Sin-Ae, Boulter, Etienne, Pisano, Sabrina, Errante, Aurélia, Tissot, Floriane S., Cailleteau, Laurence, Pons, Catherine, Ginsberg, Mark H., Féral, Chloé C.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120678/
https://ncbi.nlm.nih.gov/pubmed/25267066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0579
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