Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that, the IL-4/Irs2/Akt pathway is selectively impaired, along with decreased macrophage Irs2 expression, although IL-4/STAT6 pathway is maintaine...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Kubota, Tetsuya, Inoue, Mariko, Kubota, Naoto, Takamoto, Iseki, Mineyama, Tomoka, Iwayama, Kaito, Tokuyama, Kumpei, Moroi, Masao, Ueki, Kohjiro, Yamauchi, Toshimasa, Kadowaki, Takashi
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242852/
https://ncbi.nlm.nih.gov/pubmed/30451856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07358-9
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