Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

We previously demonstrated that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia, and leptin resistance. To more precisely determine the roles of Irs2 in β cells and the hypothalamus, we generated β cell–...

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Hlavní autoři: Kubota, Naoto, Terauchi, Yasuo, Tobe, Kazuyuki, Yano, Wataru, Suzuki, Ryo, Ueki, Kohjiro, Takamoto, Iseki, Satoh, Hidemi, Maki, Toshiyuki, Kubota, Tetsuya, Moroi, Masao, Okada-Iwabu, Miki, Ezaki, Osamu, Nagai, Ryozo, Ueta, Yoichi, Kadowaki, Takashi, Noda, Tetsuo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC518663/
https://ncbi.nlm.nih.gov/pubmed/15467830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421484
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