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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
We previously demonstrated that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia, and leptin resistance. To more precisely determine the roles of Irs2 in β cells and the hypothalamus, we generated β cell–...
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| Главные авторы: | , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC518663/ https://ncbi.nlm.nih.gov/pubmed/15467830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421484 |
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