Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet–induced insulin resistance

Glucokinase (Gck) functions as a glucose sensor for insulin secretion, and in mice fed standard chow, haploinsufficiency of β cell–specific Gck (Gck(+/–)) causes impaired insulin secretion to glucose, although the animals have a normal β cell mass. When fed a high-fat (HF) diet, wild-type mice showe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Terauchi, Yasuo, Takamoto, Iseki, Kubota, Naoto, Matsui, Junji, Suzuki, Ryo, Komeda, Kajuro, Hara, Akemi, Toyoda, Yukiyasu, Miwa, Ichitomo, Aizawa, Shinichi, Tsutsumi, Shuichi, Tsubamoto, Yoshiharu, Hashimoto, Shinji, Eto, Kazuhiro, Nakamura, Akinobu, Noda, Mitsuhiko, Tobe, Kazuyuki, Aburatani, Hiroyuki, Nagai, Ryozo, Kadowaki, Takashi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2007
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716196/
https://ncbi.nlm.nih.gov/pubmed/17200721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI17645
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg