Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

Non-insulin-dependent diabetes mellitus (NIDDM) is considered a polygenic disorder in which insulin resistance and insulin secretory defect are the major etiologic factors. Homozygous mice with insulin receptor substrate-1 (IRS-1) gene knockout showed normal glucose tolerance associated with insulin...

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Autori principali: Terauchi, Y, Iwamoto, K, Tamemoto, H, Komeda, K, Ishii, C, Kanazawa, Y, Asanuma, N, Aizawa, T, Akanuma, Y, Yasuda, K, Kodama, T, Tobe, K, Yazaki, Y, Kadowaki, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1997
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC507893/
https://ncbi.nlm.nih.gov/pubmed/9062343
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