Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet–induced insulin resistance

Glucokinase (Gck) functions as a glucose sensor for insulin secretion, and in mice fed standard chow, haploinsufficiency of β cell–specific Gck (Gck(+/–)) causes impaired insulin secretion to glucose, although the animals have a normal β cell mass. When fed a high-fat (HF) diet, wild-type mice showe...

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Main Authors: Terauchi, Yasuo, Takamoto, Iseki, Kubota, Naoto, Matsui, Junji, Suzuki, Ryo, Komeda, Kajuro, Hara, Akemi, Toyoda, Yukiyasu, Miwa, Ichitomo, Aizawa, Shinichi, Tsutsumi, Shuichi, Tsubamoto, Yoshiharu, Hashimoto, Shinji, Eto, Kazuhiro, Nakamura, Akinobu, Noda, Mitsuhiko, Tobe, Kazuyuki, Aburatani, Hiroyuki, Nagai, Ryozo, Kadowaki, Takashi
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716196/
https://ncbi.nlm.nih.gov/pubmed/17200721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI17645
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