Tamoxifen therapy in a murine model of myotubular myopathy

Myotubular myopathy (MTM) is a severe X-linked disease without existing therapies. Here, we show that tamoxifen ameliorates MTM-related histopathological and functional abnormalities in mice, and nearly doubles survival. The beneficial effects of tamoxifen are mediated primarily via estrogen recepto...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Maani, Nika, Sabha, Nesrin, Rezai, Kamran, Ramani, Arun, Groom, Linda, Eltayeb, Nadine, Mavandadnejad, Faranak, Pang, Andrea, Russo, Giulia, Brudno, Michael, Haucke, Volker, Dirksen, Robert T., Dowling, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242823/
https://ncbi.nlm.nih.gov/pubmed/30451841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07057-5
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