Next generation sequencing of circulating cell-free DNA evaluating mutations and gene amplification in metastatic breast cancer

BACKGROUND: Breast cancer tissues are heterogeneous and show diverse somatic mutations and somatic copy number alterations (CNAs). We used a novel targeted next generation sequencing (NGS) panel to examine cell-free DNA (cfDNA) to detect somatic mutations and gene amplification in women with metasta...

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Vydáno v:Clin Chem
Hlavní autoři: Page, Karen, Guttery, David S., Fernandez-Garcia, Daniel, Hills, Allison, Hastings, Robert K., Luo, Jinli, Goddard, Kate, Shahin, Vedia, Woodley-Barker, Laura, Rosales, Brenda M., Coombes, R. Charles, Stebbing, Justin, Shaw, Jacqueline A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6241835/
https://ncbi.nlm.nih.gov/pubmed/27940449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2016.261834
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