The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA

Sirtuin 3 (SIRT3) deacetylates and activates several mitochondrial fatty acid oxidation enzymes in the liver. Here, we investigated whether the protein acetylase GCN5 general control of amino acid synthesis 5-like 1 (GCN5L1), previously shown to oppose SIRT3 activity, is involved in the regulation o...

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Pubblicato in:J Biol Chem
Autori principali: Thapa, Dharendra, Wu, Kaiyuan, Stoner, Michael W., Xie, Bingxian, Zhang, Manling, Manning, Janet R., Lu, Zhongping, Li, Jian H., Chen, Yong, Gucek, Marjan, Playford, Martin P., Mehta, Nehal N., Harmon, Daniel, O'Doherty, Robert M., Jurczak, Michael J., Sack, Michael N., Scott, Iain
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Accelerated Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240879/
https://ncbi.nlm.nih.gov/pubmed/30323061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC118.005462
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