Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging

Androgens such as testosterone and dihydrotestosterone are a critical driver of prostate cancer progression. Cancer resistance to androgen deprivation therapies ensues when tumors engage metabolic processes that produce sustained androgen levels in the tissue. However, the molecular mechanisms invol...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Zhu, Ziqi, Chung, Yoon-Mi, Sergeeva, Olga, Kepe, Vladimir, Berk, Michael, Li, Jianneng, Ko, Hyun-Kyung, Li, Zhenfei, Petro, Marianne, DiFilippo, Frank P., Lee, Zhenghong, Sharifi, Nima
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240862/
https://ncbi.nlm.nih.gov/pubmed/30262668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004846
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