Direct metabolic interrogation of dihydrotestosterone biosynthesis from adrenal precursors in primary prostatectomy tissues

PURPOSE: A major mechanism of castration-resistant prostate cancer (CRPC) involves intratumoral biosynthesis of dihydrotestosterone (DHT) from adrenal precursors. We have previously shown that adrenal-derived androstenedione (AD) is the preferred substrate over testosterone (T) for 5α-reductase expr...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Dai, Charles, Chung, Yoon-Mi, Kovac, Evan, Zhu, Ziqi, Li, Jianneng, Magi-Galluzzi, Cristina, Stephenson, Andrew J., Klein, Eric A., Sharifi, Nima
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641243/
https://ncbi.nlm.nih.gov/pubmed/28733443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1313
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