Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging

Androgens such as testosterone and dihydrotestosterone are a critical driver of prostate cancer progression. Cancer resistance to androgen deprivation therapies ensues when tumors engage metabolic processes that produce sustained androgen levels in the tissue. However, the molecular mechanisms invol...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhu, Ziqi, Chung, Yoon-Mi, Sergeeva, Olga, Kepe, Vladimir, Berk, Michael, Li, Jianneng, Ko, Hyun-Kyung, Li, Zhenfei, Petro, Marianne, DiFilippo, Frank P., Lee, Zhenghong, Sharifi, Nima
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240862/
https://ncbi.nlm.nih.gov/pubmed/30262668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004846
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