Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector

Intra-embryo genome editing by CRISPR/Cas9 enables easy generation of gene-modified animals by non-homologous end joining (NHEJ)-mediated frameshift mutations or homology-directed repair (HDR)-mediated point mutations. However, large modifications, such as gene replacement or gene fusions, are still...

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Publicat a:iScience
Autors principals: Mizuno, Naoaki, Mizutani, Eiji, Sato, Hideyuki, Kasai, Mariko, Ogawa, Aki, Suchy, Fabian, Yamaguchi, Tomoyuki, Nakauchi, Hiromitsu
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240711/
https://ncbi.nlm.nih.gov/pubmed/30447647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.10.030
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