T-cell responses to TP53 “hotspot” mutations and unique neoantigens expressed by human ovarian cancers

PURPOSE: This was a study prospectively evaluating intratumoral T-cell responses to autologous somatic mutated neoepitopes expressed by human metastatic ovarian cancers. EXPERIMENTAL DESIGN: Tumor infiltrating lymphocytes (TILs) were expanded from resected ovarian cancer metastases, which were analy...

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Pubblicato in:Clin Cancer Res
Autori principali: Deniger, Drew C., Pasetto, Anna, Robbins, Paul F., Gartner, Jared J., Prickett, Todd D., Paria, Biman C., Malekzadeh, Parisa, Jia, Li, Yossef, Rami, Langhan, Michelle M., Wunderlich, John R., Danforth, David N., Somerville, Robert P.T., Rosenberg, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239943/
https://ncbi.nlm.nih.gov/pubmed/29853601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0573
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