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Elimination of 01/A′–A0 pre-rRNA processing by-product in human cells involves cooperative action of two nuclear exosome-associated nucleases: RRP6 and DIS3

Pre-rRNA processing generates mature 18S, 5.8S, and 28S/25S rRNAs through multistage removal of surrounding 5′-ETS/3′-ETS and intervening ITS1/ITS2 segments. Endonucleolytic activities release by-products, which need to be eliminated. Here, we investigated the interplay of exosome-associated 3′–5′ e...

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Bibliografske podrobnosti
izdano v:RNA
Main Authors: Kobyłecki, Kamil, Drążkowska, Karolina, Kuliński, Tomasz M., Dziembowski, Andrzej, Tomecki, Rafał
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239190/
https://ncbi.nlm.nih.gov/pubmed/30266864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.066589.118
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