Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs

The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells. We show that DIS3L2 regulates pol II transcripts, comprising selected canonical and histo...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Łabno, Anna, Warkocki, Zbigniew, Kuliński, Tomasz, Krawczyk, Paweł Szczepan, Bijata, Krystian, Tomecki, Rafał, Dziembowski, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137419/
https://ncbi.nlm.nih.gov/pubmed/27431325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw649
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