Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs

The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells. We show that DIS3L2 regulates pol II transcripts, comprising selected canonical and histo...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Łabno, Anna, Warkocki, Zbigniew, Kuliński, Tomasz, Krawczyk, Paweł Szczepan, Bijata, Krystian, Tomecki, Rafał, Dziembowski, Andrzej
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137419/
https://ncbi.nlm.nih.gov/pubmed/27431325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw649
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