Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target

hDIS3 is a mainly nuclear, catalytic subunit of the human exosome complex, containing exonucleolytic (RNB) and endonucleolytic (PIN) active domains. Mutations in hDIS3 have been found in ∼10% of patients with multiple myeloma (MM). Here, we show that these mutations interfere with hDIS3 exonucleolyt...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tomecki, Rafal, Drazkowska, Karolina, Kucinski, Iwo, Stodus, Krystian, Szczesny, Roman J., Gruchota, Jakub, Owczarek, Ewelina P., Kalisiak, Katarzyna, Dziembowski, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902924/
https://ncbi.nlm.nih.gov/pubmed/24150935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt930
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados