DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts

Human DIS3, the nuclear catalytic subunit of the exosome complex, contains exonucleolytic and endonucleolytic active domains. To identify DIS3 targets genome-wide, we combined comprehensive transcriptomic analyses of engineered HEK293 cells that expressed mutant DIS3, with Photoactivatable Ribonucle...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Res
Main Authors: Szczepińska, Teresa, Kalisiak, Katarzyna, Tomecki, Rafal, Labno, Anna, Borowski, Lukasz S., Kulinski, Tomasz M., Adamska, Dorota, Kosinska, Joanna, Dziembowski, Andrzej
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617959/
https://ncbi.nlm.nih.gov/pubmed/26294688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.189597.115
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