Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants

The most severe manifestation of peripheral arterial disease (PAD) is critical limb ischemia (CLI). CLI patients suffer high rates of amputation and mortality; accordingly, there remains a clear need both to better understand CLI and to develop more effective treatments. Gastrocnemius muscle was obt...

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Vydáno v:JCI Insight
Hlavní autoři: Ryan, Terence E., Yamaguchi, Dean J., Schmidt, Cameron A., Zeczycki, Tonya N., Shaikh, Saame Raza, Brophy, Patricia, Green, Thomas D., Tarpey, Michael D., Karnekar, Reema, Goldberg, Emma J., Sparagna, Genevieve C., Torres, Maria J., Annex, Brian H., Neufer, P. Darrell, Spangenburg, Espen E., McClung, Joseph M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238738/
https://ncbi.nlm.nih.gov/pubmed/30385731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123235
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