Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants

The most severe manifestation of peripheral arterial disease (PAD) is critical limb ischemia (CLI). CLI patients suffer high rates of amputation and mortality; accordingly, there remains a clear need both to better understand CLI and to develop more effective treatments. Gastrocnemius muscle was obt...

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Pubblicato in:JCI Insight
Autori principali: Ryan, Terence E., Yamaguchi, Dean J., Schmidt, Cameron A., Zeczycki, Tonya N., Shaikh, Saame Raza, Brophy, Patricia, Green, Thomas D., Tarpey, Michael D., Karnekar, Reema, Goldberg, Emma J., Sparagna, Genevieve C., Torres, Maria J., Annex, Brian H., Neufer, P. Darrell, Spangenburg, Espen E., McClung, Joseph M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238738/
https://ncbi.nlm.nih.gov/pubmed/30385731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123235
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