Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants

The most severe manifestation of peripheral arterial disease (PAD) is critical limb ischemia (CLI). CLI patients suffer high rates of amputation and mortality; accordingly, there remains a clear need both to better understand CLI and to develop more effective treatments. Gastrocnemius muscle was obt...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ryan, Terence E., Yamaguchi, Dean J., Schmidt, Cameron A., Zeczycki, Tonya N., Shaikh, Saame Raza, Brophy, Patricia, Green, Thomas D., Tarpey, Michael D., Karnekar, Reema, Goldberg, Emma J., Sparagna, Genevieve C., Torres, Maria J., Annex, Brian H., Neufer, P. Darrell, Spangenburg, Espen E., McClung, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238738/
https://ncbi.nlm.nih.gov/pubmed/30385731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123235
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