Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT) and remains an area of unmet clinical need with few treatment options available. Notch blockade prevents acute GVHD in multiple mouse models, but the impact of Notch signalin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Radojcic, Vedran, Paz, Katelyn, Chung, Jooho, Du, Jing, Perkey, Eric T., Flynn, Ryan, Ivcevic, Sanja, Zaiken, Michael, Friedman, Ann, Yan, Minhong, Pletneva, Maria A., Sarantopoulos, Stefanie, Siebel, Christian W., Blazar, Bruce R., Maillard, Ivan
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2018
Sujets:
Transplantation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238189/
https://ncbi.nlm.nih.gov/pubmed/30181175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-841155
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