An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

B-cell receptor (BCR)-activated B cells contribute to pathogenesis in chronic graft-versus-host disease (cGVHD), a condition manifested by both B-cell autoreactivity and immune deficiency. We hypothesized that constitutive BCR activation precluded functional B-cell maturation in cGVHD. To address th...

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Publicado en:Blood
Autores principales: Poe, Jonathan C., Jia, Wei, Su, Hsuan, Anand, Sarah, Rose, Jeremy J., Tata, Prasanthi V., Suthers, Amy N., Jones, Corbin D., Kuan, Pei Fen, Vincent, Benjamin G., Serody, Jonathan S., Horwitz, Mitchell E., Ho, Vincent T., Pavletic, Steven Z., Hakim, Frances T., Owzar, Kouros, Zhang, Dadong, Blazar, Bruce R., Siebel, Christian W., Chao, Nelson J., Maillard, Ivan, Sarantopoulos, Stefanie
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2017
Materias:
Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680609/
https://ncbi.nlm.nih.gov/pubmed/28851699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-782466
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