An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

B-cell receptor (BCR)-activated B cells contribute to pathogenesis in chronic graft-versus-host disease (cGVHD), a condition manifested by both B-cell autoreactivity and immune deficiency. We hypothesized that constitutive BCR activation precluded functional B-cell maturation in cGVHD. To address th...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Poe, Jonathan C., Jia, Wei, Su, Hsuan, Anand, Sarah, Rose, Jeremy J., Tata, Prasanthi V., Suthers, Amy N., Jones, Corbin D., Kuan, Pei Fen, Vincent, Benjamin G., Serody, Jonathan S., Horwitz, Mitchell E., Ho, Vincent T., Pavletic, Steven Z., Hakim, Frances T., Owzar, Kouros, Zhang, Dadong, Blazar, Bruce R., Siebel, Christian W., Chao, Nelson J., Maillard, Ivan, Sarantopoulos, Stefanie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680609/
https://ncbi.nlm.nih.gov/pubmed/28851699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-782466
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