Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine

Adipocytes are the prevalent stromal cell type in adult bone marrow (BM), and leukemia cells continuously adapt to deficiency of nutrients acquiring chemoresistant profiles in the BM microenvironment. We have previously shown that fatty acid metabolism is a key energy pathway for survival of acute m...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Tabe, Yoko, Saitoh, Kaori, Yang, Haeun, Sekihara, Kazumasa, Yamatani, Kotoko, Ruvolo, Vivian, Taka, Hikari, Kaga, Naoko, Kikkawa, Mika, Arai, Hajime, Miida, Takashi, Andreeff, Michael, Spagnuolo, Paul A., Konopleva, Marina
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237992/
https://ncbi.nlm.nih.gov/pubmed/30442990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35198-6
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