Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine

Adipocytes are the prevalent stromal cell type in adult bone marrow (BM), and leukemia cells continuously adapt to deficiency of nutrients acquiring chemoresistant profiles in the BM microenvironment. We have previously shown that fatty acid metabolism is a key energy pathway for survival of acute m...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Tabe, Yoko, Saitoh, Kaori, Yang, Haeun, Sekihara, Kazumasa, Yamatani, Kotoko, Ruvolo, Vivian, Taka, Hikari, Kaga, Naoko, Kikkawa, Mika, Arai, Hajime, Miida, Takashi, Andreeff, Michael, Spagnuolo, Paul A., Konopleva, Marina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237992/
https://ncbi.nlm.nih.gov/pubmed/30442990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35198-6
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